• CVEP's reaction to the article: "Metabolomic screening of pre-diagnostic serum samples identifies association between α- and ϒ-tocopherols and glioblastoma risk. Benny Björkblom et al."

“We know this study, but due to limited data and insight into the methodology as well as conditions of the subjects, it is not possible to draw a scientifically sound conclusion at this point of time. Numerous studies show that vitamin E has a positive and beneficial impact on the health of human beings and is essential in the daily diet“.

  • Chemical Vitamin E Producers (CVEP) responds to EFSA review of vitamin E Dietary Reference Values

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Beneficial effects on human health in the field of cardiovascular disease and some cancers:

  1. Gey KF, Puska P, Jordan P, Moser UK. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr. 1991;53:326s-34s
  2. Gey KF. Prospects for the prevention of free radical disease, regarding cancer and cardiovascular disease. Br Med Bull. 1993;49:679-99
  3. Knekt P, Ritz J, Pereira MA, O'Reilly EJ, Augustsson K, Fraser GE, et al. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Am J Clin Nutr. 2004;80:1508-20
  4. Biesalski HK, Bohles H, Esterbauer H, Furst P, Gey F, Hundsdorfer G, et al. Antioxidant vitamins in prevention. Clin Nutr. 1997;16:151-5
  5. Gey KF. Cardiovascular disease and vitamins. Concurrent correction of 'suboptimal' plasma antioxidant levels may, as important part of 'optimal' nutrition, help to prevent early stages of cardiovascular disease and cancer, respectively. Bibl Nutr Dieta. 1995:75-91

Vitamin E is a powerful antioxidant and carries an approved EFSA health claim related to the protection of DNA, proteins and lipids from oxidative damage:

  1. Access EFSA Health Claim

Low intake of vitamin E is also linked to higher rate of miscarriage as well as asthma and allergies in the offsprings:

  1. Shamim AA, Schulze K, Merrill RD, Kabir A, Christian P, Shaikh S, et al. First-trimester plasma tocopherols are associated with risk of miscarriage in rural Bangladesh. Am J Clin Nutr. 2015;101:294-301
  2. Cook-Mills J.M. Maternal Influences over Offspring Allergic Responses. Current Allergy and Asthma Reports 15 (2), 2015

For selected individuals and population groups, vitamin E is understood to reduce the risk of Alzheimer’s disease:

  1. M. Dyksen et al, ‘Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease,’ Journal of the American Medical Association, Vol 311, No 1 (2014)

Limit the negative health implications of fatty liver:

  1. Sanyal A. J. et al. ‘Pioglitazone, vitamin E, or placebo for non-alcoholic steatohepatitis.’ N Engl J Med. 2010; 362(18):1675–1685

Limit the risk of air pollution:

  1. Hueylen Sue et al, ‘Effect of Vitamin C and E intake on peak respiratory flow rate of asthmatic children exposed to atmospheric particulate matter,’ Arch Environ Occup H 2013;68:80
  2. Zhang, W. et al. Nutrition solutions to counter health impact of air pollution: scientific evidence of marine omega-3 fatty acids and vitamins minimizing some harms of PM2.5. (2015) J Food Nutr Sci 2(2): 1-6

Assessment of intake of vitamin E is generally low in Europe. For example, the results of a micronutrient intake panel demonstrated that more than 75% of the population in the UK does not meet the recommended intake:

  1. Troesch, B., et al., ‘Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries.’ British Journal of Nutrition, 2012. 108(04): p. 692-698

Review of published literature reporting E intake levels and serum concentrations:

  1. Szabolcs Péter, Angelika Friedel, Franz F. Roos, Adrian Wyss, Manfred Eggersdorfer, Kristina Hoffmann, and Peter Weber, Alpha-Tocopherol Status as Assessed by Nutritional Intake Levels and Blood Serum Concentrations. Int. J. Vitam. Nutr. Res.,2016, 1 – 21